Folding Upon Binding - Not a Simple Protein Folding Problem
نویسندگان
چکیده
منابع مشابه
Simple Models of the Protein Folding Problem
The protein folding problem has attracted an increasing attention from physicists. The problem has a avor of statistical mechanics, but possesses the most common feature of most biological problems – the profound e ects of evolution. I will give an introduction to the problem, and then focus on some recent work concerning the so-called “designability principle”. The designability of a structure...
متن کاملProtein Folding: Simple Models
Doublié, S., Sawaya, M.R., and Ellenberger, T. (1999). Struct. Fold. son and Beese, 2004). The same mispair, on the other Des. 7, R31–R35. hand, is poorly extended by Dpo4: it was shown to form Echols, H., and Goodman, M.F. (1991). Annu. Rev. Biochem. 60, a reverse wobble, which misaligns the 3 -end of the 477–511. primer and therefore precludes nucleophilic attack (TrinHatahet, Z., Zhou, M., R...
متن کاملThe protein folding problem.
The "protein folding problem" consists of three closely related puzzles: (a) What is the folding code? (b) What is the folding mechanism? (c) Can we predict the native structure of a protein from its amino acid sequence? Once regarded as a grand challenge, protein folding has seen great progress in recent years. Now, foldable proteins and nonbiological polymers are being designed routinely and ...
متن کاملSimple Models of Protein Folding
Lattice models with simplified interaction potentials have been used to analyze the ability of certain amino acid sequences to adopt a unique configuration in space [1, 2, 3]. Furthermore, phenomenological models have been used to predict protein folding kinetics amongst a subset of energetically favorable states [4, 5]. In the following, I will specifically discuss both the use of two dimensio...
متن کاملA simple theory of protein folding kinetics
We present a simple model of protein folding dynamics that captures key qualitative elements recently seen in all-atom simulations. The goals of this theory are to serve as a simple formalism for gaining deeper insight into the physical properties seen in detailed simulations as well as to serve as a model to easily compare why these simulations suggest a different kinetic mechanism than previo...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2013
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2012.11.1069